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According to a 2024 review in Nature Reviews Drug Discovery , the next generation of anti-obesity medications will likely combine multiple hormonal pathways to achieve weight loss results that approach those of bariatric surgery, but without the surgical risks

Given that PYY is secreted from cells of the distal gut there must be signals associated with the response of the proximal gut to food intake that lead to PYY release

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The less than optimal dose might be a reason for these disappointing results

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