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It increases controlled hepatic glucose production, facilitates fat breakdown, and raises resting energy expenditure
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Animal studies suggest GLP-1 signaling in the brain may help recalibrate sleep-wake cycles entirely independent of body weight changes, though these findings have not yet been replicated in humans (ref)
Tirzepatide: As a newer option, Tirzepatide targets both GLP-1 and GIP receptors, making it a unique choice for those exploring different weight management solutions
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Hence, we strongly encourage the adoption of GLP-1RA plus SGLT2i combination therapy in T2DM patients with uncontrolled metabolic risks, i.e., especially those who need to lose weight and/or control high blood pressure
2018;172(e421):40922
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