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Exenatide, the first GLP-1RA approved in 2005, demonstrated clinical efficacy but its low homology with human GLP-1 and gastrointestinal side effects restricted widespread use (Muttenthaler et al., 2021)

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As the cell-cell interaction is weak at low concentration, becoming repulsive at high concentration and attractive in between, f ( c ) in Eq.(4) has a simple form reminding the Lennard-Jones potential (see Fig

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Nevertheless, the compound itself has a well-established track record