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For instance, doctors may treat a B12 deficiency with several shots in the first month, followed by monthly or quarterly injections for maintenance

a composite renal outcome of development of macroalbuminuria, doubling of serum creatinine, or at least 40% decline in eGFR, renal replacement therapy or death due to kidney disease

Brunel-Guitton C, Costa T, Mitchell GA, Lambert M

Cancer cachexia not only negatively affects the quality of life of patients, but is also associated with a reduced efficacy and increased toxicity of chemotherapy, thereby contributing to mortality [34]

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