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When NNMT activity is inhibited, these methyl donors become available for other methylation reactions in the body
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Monitoring: As with any IV push, administration by or under the supervision of a trained clinician with appropriate monitoring is recommended
Anyway, pro-apoptotic effects were observed in HL60 cells incubated with HOTYR even in conditions not supporting H2O2 accumulation (between 23.8 and 38.0% depending on the media) suggesting that other mechanisms, in addition to the H2O2-releasing activity, could be involved in the pro-apoptotic activity (80)
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