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Liraglutide improves water Maze learning and memory performance while reduces hyperphosphorylation of tau and neurofilaments in APP/PS1/Tau triple transgenic mice

The mechanism works because amino acids from protein digestion directly activate nutrient-sensing receptors in the gut lining

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To date, all these peptides have followed similar trajectories: promising animal data with no evidence of efficacy in humans, despite extensive advertising and widespread availability of these compounds to athletes, Ellis and colleagues wrote in their AOSSM article

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glucose-6-phosphate dehydrogenase, the rate limiting enzyme of the reaction, while also reducing NADP + to NADPH