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(2015) documented that oral glutathione at 250-1000 mg daily for 6 months did increase blood, erythrocyte, and lymphocyte glutathione levels, though the magnitude of increase was smaller than injectable or IV routes (Richie et al., 2015)

This regulatory mechanism may stem from its detergent-like effect, which affects the structure and function of the cell membrane [122]

However, like all research peptides, it must be used only in non-human laboratory settings , and should never be promoted or interpreted as a therapeutic product

Funding This work was supported by grants from the National Natural Science Foundation of China (NSFC Numbers 81672800, 81603009, 81673020, 81802632, and 82173830), Natural Science Foundation of Shaanxi (2020JQ-445), and the Key Research and Development Program of Shaanxi Province (2021SF-207, 2021SF-223, and 2022ZDLSF05-19)

It is studied as a direct scavenger of reactive oxygen species and as a cofactor for glutathione peroxidase and glutathione-S-transferase enzyme systems

The combination significantly outperformed both monotherapies