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doi: 10.1056/NEJMoa1603827 13 MarsoSPBainSCConsoliAEliaschewitzFGJodarELeiterLAet al

Both immunoreactive gut glucagon and L-cells are present most abundantly in the distal small intestine and colon (31, 62)

For the chronic dosing studies, most studies are looking at doses of 4 g/day.[ref] (This used to be the maximum recommended acetaminophen dose per day, but that has now changed to 3g/day.) For reference, a single over-the-counter Extra Strength Tylenol is 500 mg, with the directions saying not to exceed 6 tablets in 24 hours (so 3g/day)

So all of those changes conspire to put weight on

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A family history of obesity, type 2 diabetes, cardiovascular disease, or metabolic syndrome can strengthen your case for medical necessity, even if it does not formally change the BMI threshold