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Clin Pharmacol Ther 2011;89(6): 806-15
In preclinical models, co-administration of bimagrumab or dual myostatin/activin A inhibitors with GLP-1R agonists preserves or increases muscle mass while enhancing fat loss, resulting in improved body composition and metabolic outcomes compared with GLP-1R agonist monotherapy [176]
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In both experimental models and human diabetic subjects, there is an initial metabolic phase that is responsive to metabolic corrections [90, 91]
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