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doi: 10.1002/jlb.3ma1217-502r 105 YangMHWuFXXieCMQingYFWangGRGuoXLet al
Acetyl-L-carnitine has been shown to: Promote fatty acid and carbohydrate metabolism
However, the largest Phase IIb trial involving 536 subjects failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading Metabolic Pharmaceuticals to terminate development in 2007
Individual responses vary considerably, and what works well for one patient may not be optimal for another
However, practical considerations exist
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