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Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT
Selective pretreatment of endothelial cells with methylene blue before co-culture with untreated rabbit pulmonary arterial smooth muscle produced a reduction in rabbit pulmonary arterial smooth muscle cyclic guanosine monophosphate levels of a magnitude comparable with that seen in cocultures of methylene blue pretreated rabbit pulmonary arterial smooth muscle with untreated endothelial cells, and which was partially prevented by superoxide dismutase
Side effects The most common side effects include nausea, vomiting, and diarrhea, necessitating a slow titration of the dose to ensure tolerance
Our study provided valuable evidence for early clinical interventions and the identification of the risk of gastrointestinal toxicities
International Journal of Impotence Research, 16 (2), 135-142
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