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Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

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Funding This work was supported by the United States Department of Defense through a Congressionally Directed Medical Research Program Award (W81XWH1010299) to R.P.D

Suppression of Glucagon Secretion These agents reduce glucagon secretion from pancreatic alpha cells, particularly during hyperglycemia, which helps decrease hepatic glucose output