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Too much water and you will have an extremely dilute solution where huge volumes are needed per dose

Popular Peptide Supplements Several natural and synthetic peptides are available over the counter as topical or oral supplements, including the following: Collagen peptides stimulate the production of collagen and elastin proteins found in healthy skin, bone, and cartilage

Also, one less metabolic step is needed for the conversion of hydroxocobalamin than cyanocobalamin

2025 Dec;18(12):611-619

An earlier landmark study by Staresinic et al

The FDA placed it in 503A Category 2 ("may present significant safety risks") in 2023, effectively barring compounding pharmacies from using it, then removed it from that category in April 2026 after nominators withdrew their submission, without adding it to the approved Category 1 compounding list