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Understanding these biological mechanisms helps explain why hair loss occurs and why its typically temporary
While GI side effects have been suggested to be involved in mediating the weight-loss effect of GLP-1RAs, analysis of large clinical trial data sets with liraglutide and semaglutide has shown that, while GI side effects may lead to more initial weight loss, they are not the mechanism of weight loss as many patients have weight loss and no side effects (182, 183)
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The case for considering it is straightforward: the underlying drug class (GLP-1 receptor agonists) has the strongest weight management evidence base in clinical pharmacology, supported by multiple large-scale randomized controlled trials showing 15-22% weight reduction in study populations over 68-72 weeks
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