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IL-2 suppression of IL-12p70 by a RecombinantHSV-1 expressing IL-2 induces T-cell auto-reactivity and CNS demyelination
An extra lysine residue is added beyond the endogenous sequence, bearing a chemical modification referred to as N-3-maleimidopropionic acid (MPA)
For instance, trastuzumab (a monoclonal antibody) is designed to target the HER2 receptor in the case of HER2-positive tumors, where it has demonstrated a significant improvement in survival rates (disease-free as well as overall survival) in early stage and metastatic disease settings (217)
However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers
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