Contact your GP within 2448 hours for: Persistent pale or grey stools without jaundice Unexplained changes in stool colour lasting more than a few days Greasy, foul-smelling stools that float (steatorrhoea) suggesting fat malabsorption Stool changes accompanied by unexplained weight loss, fever, or night sweats Severe or persistent diarrhoea (more than seven days) or constipation unresponsive to usual measures It is particularly important to report stool changes if you have a history of gallbladder disease, pancreatitis, or inflammatory bowel conditions
Hair loss is not widely discussed as a potential effect of GLP-1 therapy, yet it appeared repeatedly in the database
Bone 87 , 130135 (2016)
Translational and therapeutic perspectives Despite the robust adipose tissue remodeling observed in this study, several limitations should be acknowledged
Zepbound (tirzepatide) studies generally show marginally better average weight loss outcomes compared to semaglutide at equivalent doses but Wegovy is highly effective, extensively studied, and costs the same copay on plans where it's preferred
Animal research suggests several converging mechanisms: modulation of the nitric oxide pathway , upregulation of VEGF driving angiogenesis, interaction with the growth-hormone-receptor pathway , and modulation of inflammatory cytokines including TNF- and IL-6