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Enhanced medullary and extramedullary granulopoiesis sustain the inflammatory response in lupus nephritis

ATTAIN-2 (NCT05872620) was a Phase III, 72-week, randomized, double-blind, placebo-controlled trial comparing the efficacy and safety of various doses of orforglipron with placebo in adults with obesity or overweight and type 2 diabetes

In studies of healthy adults, CJC-1295 has been shown to activate the growth hormone and IGF-1 axis (Teichman et al., 2006)

While AEs associated with these agents have been investigated 19,36,37 , our analysis reveals critical gaps in understanding their NAEs given the central nervous system penetration and expanding indications of GLP-1 RAs

This is the intended therapeutic effect, but it can feel unusual initially

No other option beats this for covered patients