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To this regard, GSH may also have direct anti-SARS-CoV-2 potential: indeed a computational study indicates that the binding of spike protein to ACE2 is maximal when ACE2-sulfur groups are in the form of disulfides and impaired when fully reduced to thiols: hence a prooxidant environment with low levels of GSH would favor viruses cellular entry (Hati and Bhattacharyya, 2020)

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Importantly, exendin-4 demonstrated resistance to DPP-4 degradation, giving it a significantly longer half-life than native human GLP-1

10.1016/S0731-7085(03)00573-9