ALS is mostly diagnosed based on clinical signs, using the revised El Escorial criteria, which require signs of both upper motor neuron (e.g., spasticity, brisk reflexes) and lower motor neuron damage (e.g., muscle wasting, twitching) in multiple body regions (Brotman et al., 2025)
This led to it being used off-label as a weight loss drug
Most events were mild to moderate in severity, transient, and peaked during the first 1 to 2 weeks after the dose increase
It can be treated with vitamin B12 medications
They remove damaged proteins (which gather up to form scars on the surface) such as the damaged collagen and elastin
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