Although the hypotensive effect of GLP-1 RAs seems to be manifested by BW losing, other mechanisms not related to BW might be implied by the mediation meta-analysis, which suggests an existence of BW-independent hypotensive effect of GLP-1 RA, along with the clinical evidence of weak or no correlations, and difference in time course between BP lowering and BW reducing effects
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This combined mechanism enhances appetite control, increases energy expenditure, and optimizes nutrient partitioning
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In INGs research, it predicted that in almost any potential future, GLP-1 uptake will remain a minority
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