does semaglutide cause leg pain Comparative safety and side effects of semaglutide and tirzepatide: Implications for clinical decision-making in obesity management TrimRX | Is Leg Pain

Importantly, these GI side effects, including constipation, were mostly non-serious, and only a few people (4.3%) stopped treatment

Mechanistic reviews highlight direct effects at GLP1R on islets, brain, and GI tract that explain both efficacy and common GI side effects

2008 Dec;138(12):2356-62

Molinoff PB et al

Dramatically reduced calorie intake, rapid weight loss, possible dehydration, metabolic adjustments, and changes in blood sugar levels all contribute to feelings of tiredness, particularly during the first few weeks of treatment and when increasing doses

It appeared to lower the intensity of H2AX signals a marker of DNA damage and seemed to decrease apoptosis rates, as indicated by reduced Annexin-V staining