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Problems arise when nitric oxide production decreases or when the molecule gets broken down too quickly
This doesn't mean they're dangerous or ineffective, but it does mean: Limited clinical data: Without the trials required for approval, human data remains sparse
Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program
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