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FDA drug approval requires standardized clinical trials
Osteocalcin induces proliferation via positive activation of the PI3K/Akt, P38 MAPK pathways and promotes differentiation through activation of the GPRC6A-ERK1/2 pathway in C2C12 myoblast cells
PMID: 14984373
Cardiovasc Diabetol 20:205
Relative to single-pathway compounds, this combination provides a more refined framework for studying endocrine feedback loops and the coordinated architecture of metabolic signaling
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