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More data on the long-term effects of GLP-1 receptor agonists and how best to use them for patients will likely come in the future

Lu M (2026)

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[54] in women with PCOS, BMI 25 kg/m 2 and/or insulin resistance, treatment with liraglutide 1.8 mg/day for 26 weeks, along with a higher weight loss, induced significant reductions in fasting plasma glucose, HbA1c, and plasma glucose AUC, whereas Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), Matsuda index and insulin AUC remained unchanged

The peptide itself is typically administered subcutaneously, where it is absorbed into the bloodstream, distributed through the body, and then cleared by enzymatic degradation and renal excretion

D., Joo, H., Mosberg, H