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The receptor that spadin and PE-22-28 primarily bind to is TREK-1 (TIWK-related-potassium channel) which is mostly found in the brain and lung tissue, heart, smooth muscle, prostate, and specific areas of the pancreas
NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinsons disease
10.3748/WJG.V28.I47.6743 11 BarberioB.ZamaniM.BlackC
Berberine administration is evidenced to improve cognitive impairment and neurological deficits and reduce brain edema in rodent models of TBI
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