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Immune-checkpoint protein VISTA regulates antitumor immunity by controlling myeloid cell-mediated inflammation and immunosuppression

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Experimental investigations have reported increased expression of angiogenic mediators and enhanced vascularization in various laboratory models

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However, tumor-associated blood vessels are dysfunctional and leaky (93), and the continuous exposure of BECs to pro-angiogenic factors can lead to endothelial anergy, a state in which ECs stop responding to inflammatory signals (90)