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A recent observational study saw tirzepatide outperform Novos semaglutide in helping patients to lose weight, and some analysts predict Lilly will indeed gain majority market share within a few years in part due to this potential efficacy advantage, though manufacturing is a complicating factor that currently favors Novo

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Rare but serious adverse effects include pancreatitis (though causality remains uncertain), gallbladder disease, and potential thyroid C-cell tumors (observed in rodent studies but not conclusively demonstrated in humans)