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Important caveat: human efficacy is unproven
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At the same time, autophagy (including mitophagy) in T-cells might be induced by surgical stress as a survival mechanism
Serious reactions to vitamin B12 are very rare, and most people will never experience them
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In addition to PDHC and OGDH(L)C, this action of thiamine is mediated by two other ThDP-dependent multienzyme complexes, i.e., those of branched chain 2-oxo acid dehydrogenase (BCODH) and OADH, functioning in the pathways of degradation of branched-chain -amino acids, and lysine and tryptophan, respectively (Figure 1)
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