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The risk of renal adverse reactions was increased in patients with a history of renal impairment (the weight management trials included 65 patients with a history of moderate or severe renal impairment at baseline), and occurred more frequently during dose titration

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While in the body, it has shown the ability to regulate sleep cycles, modulate stress hormones like cortisol, and even influence pituitary hormone release (Such as LH or GH)

There is no published data on use in pregnant or lactating animals, on paediatric exposure, or on long-term effects in humans beyond the open-label gerontology cohorts