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Both 25-hydroxylases (CYP2R1 and CYP27A1) were expressed in the liver, while CYP27A1 expression was seen only in cultured hepatocytes (FL83B mouse hepatocyte cell line)
doi: 10.3390/ijms241713317 194 DongJYuanLHuCChengXQinJ-J
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In clinical trials, GI side effects occur in roughly 4050% of patients on either medication, though they are typically mild to moderate and tend to improve over the first 812 weeks
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