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In our study, the dependency on GSH in VRK2-KO cells was identified using a synthetic lethal pharmacological screening strategy
Sumars electrodermal assessment is particularly useful for quantifying histamine overload and identifying dietary triggers
This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with
Following 6 wk of ethanol administration, GCLM knockout mice were resistant to alcohol-induced steatosis and exhibited beneficial metabolic and stress responses to chronic ethanol consumption
As reported for nitric oxide synthase whose K M value for arginine is much greater in cells than that in assay tubes (Wu and Meininger 2000), it is possible that the K M of carnosine synthetase for histidine in vivo is much greater than that (i.e., 16.8 M) reported for the purified enzyme under in vitro assay conditions, due to complex proteinprotein and enzymesubstrate interactions in vivo
Brain Res 773:139148 Allaman I, Belanger M, Magistretti PJ (2011) Astrocyte-neuron metabolic relationships: for better and for worse
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