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Given that BC is more prevalent in women of advanced age and the differential impact of advanced age-related biology on tumor growth in our models of TNBC, it will be important for future preclinical studies to consider age in their study design and data interpretation
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While abrupt discontinuation may be appropriate in certain situations, a collaborative discussion often produces better outcomes
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Most commonly, this means insulin through multiple daily injections or an insulin pump, though some providers use metformin as an adjunct since its generally considered safe in pregnancy
