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For nausea and early satiety , which are particularly common during dose escalation, the approach differs

Additionally, GLP-1 receptor agonists slow gastric emptying, which prolongs the feeling of fullness after eating, and they act on appetite centres in the hypothalamus to reduce hunger and food intake

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Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: role of L-type voltage-sensitive Ca2+ channels

This is why queasiness can occur even when someone has eaten very little, since it is not purely a matter of stomach volume, and the practical implication is that the fixes combine eating differently with giving the drug's signaling time to settle

Some patients tolerate one far better than the other, and there's no reliable way to know in advance