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Think of DSIP as addressing wellness at the source

Long-term data from the SEQUEL extension study followed Qsymia participants for an additional year, demonstrating maintained weight loss of 9.3% at 108 weeks

Current studies suggest that peripherally administered GLP-1RA has low concentrations in the cerebrospinal fluid, and higher doses or improved delivery systems (e.g., nanoparticles, liposome encapsulation) may be needed to increase brain exposure

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Mechanistic studies in apoE/ mice reveal that TMAO activates the FXR/SHP axis, specifically repressing Cyp7a1the rate-limiting enzyme in bile acid synthesisthereby blocking classical bile acid synthesis and reducing cholesterol excretion

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