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Signaling pathways documented in literature: Follicle stimulation Ex vivo models of human hair follicles document elongation and proliferation of dermal papilla cells Copper Signaling: The copper (II) complex is associated in literature with extracellular matrix modulation and dermal angiogenesis DOCUMENTED SCIENTIFIC EVIDENCE Pyo HK et al., Biol Pharm Bull 2007 (PMID 17703734): AHK-Cu in in vitro human hair follicle growth and dermal papilla cell proliferation studies Pickart L, Margolina A, Int J Mol Sci 2018 (PMID 30041448): Copper peptide review in dermal remodeling and extracellular matrix Research material only

Khadir F, Pouramir M, Joorsaraee SG, Feizi F, Sorkhi H, Yousefi F

The peptide is currently sold for research purposes only and lacks FDA approval for human therapeutic use

Some peptides that are commonly used in therapy include: BPC-157: Well known to have healing abilities

Ethics declarations Competing interests KGW and VJNB are co-founders and shareholders of Aprea Therapeutics AB, a company that develops novel p53-based cancer therapy

From a clinical perspective, reducing ZnT8 transport activity or down-regulating its cellular expression is proposed as an anti-diabetogenic strategy, mimicking the protective effect of SLC30A8 haploinsufficiency in humans