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Clinical studies have shown no major differences in clearance time across most patient groups with liver and kidney problems
These are not subtle shifts
A 2023 systematic review and meta-analysis looking into creatines role in muscle hypertrophy concluded that creatine supplementation combined with resistance training promotes a small increase in the direct measures of skeletal muscle hypertrophy in both the upper and lower body.30 That means there was a definitive improvement in muscle growth for participants adding creatine to their workouts, compared to those who didnt, across ten qualified studies
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