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FOXO4-DRI prompted relocation of p53-pS15 and FOXO4 in the serum limitation-induced senescent fibroblast model Double immunofluorescence staining was performed to investigate the distribution of p53-pS15 and FOXO4 in serum limitation-induced senescent fibroblasts model with or without treatment with FOXO4-DRI (Fig

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During the malignant progression of tumors, a variety of signaling pathways are activated to participate in the proliferation, migration, angiogenesis and metabolic remodeling of tumor cells, among which IGFs play important regulatory roles (76)