Other far less common side effects include risk of infection and anaphylaxis, an extremely rare allergic reaction
Ther Drug Monit
The latter is referred to as the senesence associated secretory phenotype (SASP) and this is considered to be driving many aspects of functional decline
SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials
Another mode of GSH depletion occurs through GSH transferase-mediated reactions where DEM, an electrophilic reagent and a mildly reactive alpha, unsaturated carbonyl compound conjugates with GSH which is catalyzed by GSH transferase which leads to the formation of hydrophilic GSH conjugates and causes rapid depletion of GSH [11, 92, 27] [90]
The pharmacokinetic study found a C_max of 4 h and a terminal half-life of 12.6 h, and statistically significant improvements in motor (MDS-UPDRS), non-motor (NMSQuest) functions, as well as in the quality of life were observed
