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Those who are pregnant or planning to become pregnant should avoid Jardiance, as it is contraindicated during pregnancy
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Tirzepatide offers dual agonist activity, targeting both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, which may contribute to its enhanced weight loss efficacy compared to single-receptor agonists
2 Several factors contribute to this: AEDs such as sodium valproate, carbamazepine, gabapentin, and pregabalin are associated with weight gain Seizure-related fatigue and activity restrictions can reduce physical activity levels Some people with epilepsy experience changes in appetite regulation Obesity itself has been associated with a 2.3-fold increased risk of drug-resistant epilepsy 3 This creates a cycle where AEDs contribute to weight gain, and excess weight may worsen seizure control
Without medical oversight, GLP-1 medications can lead to serious risks
Some research indicates berberine may influence gut microbiota composition and affect lipid metabolism, potentially reducing cholesterol and triglyceride levels
Most participants were female (236 (77.6%)) and white (283 (93.1%)), with a mean (s.d.) age of 47.3 (11.0) years, body mass index of 38.5 (6.9) kg m-2 and weight of 106.0 (22.0) kg
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