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The CiticOline Brain Injury Trial (COBRIT) has enrolled 1,213 patients with mild-to-severe TBI and assessed the effect of enteral or oral citicoline (2,000 mg/day, for 90 days) on functional and cognitive outcomes (measured by components of the TBI Clinical Trials Network Care Battery) (103)

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A further driver of nerve injury is heightened OS, which has been implicated in the progression of nerve injury in diabetic patients, as it can lead to cellular damage and apoptosis of neurons and Schwann cells (Pang et al., 2020)

injections of 100 nmol kg 1 GLP-1MK-801, 10 nmol kg 1 semaglutide or vehicle (isotonic saline) based on baseline running wheel distance measurements, such that each group had similar average running wheel distances at the day of study initiation