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The key efflux pumps present in the BBB comprise P-glycoprotein (P-gp), the breast cancer resistance protein, and various drug resistance-associated proteins[37]

Halestrap AP, Doran E, Gillespie JP, OToole A

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Disruption of microbial ecology, due to antibiotics, low fiber intake, or ultra-processed foods, impairs SCFAs and bile-acid metabolism, contributing to delayed transit and dysmotility

People expecting stimulant-like acceleration tend not to be a match