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doi: 10.1053/j.gastro.2018.11.029 161 SzczeklikKKrzyciakWCiborDKozioKPocztarHPytko-PoloczykJet al

Melatonin is a well-studied sleep-timing hormone

[5] Pyridoxine (vitamin B) is converted to pyridoxal-5-phosphate, a coenzyme for over 100 enzymes in amino acid metabolism

These include mitogen-activated protein kinase and nuclear factor-B (NF-B), which lead to the expression of inflammatory cytokines, chemokines, and adhesion molecules

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HR, Hazard Ratio