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Damaged endothelium not only stimulates neutrophils to burst-release NETs, but NETs in turn induce endothelial cells to highly express biologically active tissue factor (TF), forming a malignant pro-coagulant positive feedback loop ( 6.3 Cuproptosis: a new metabolic horizon of vascular injury Cuproptosis, as a novel form of regulated cell death distinct from oxidative stress-driven ferroptosis, is essentially mitochondrial metabolic toxicity triggered by intracellular copper ion overload ( In this pathological process, it is theoretically plausible that the functional dimensions of endothelial-derived exosomes extend beyond being passive carriers of metabolic waste

In the SMILES trial, only participants with major depressive episodes were included, and they found significant improvement in depression and noted 32.3% of their sample achieved remission after 12 weeks on the diet (122)

Right now, the only options on the market are semaglutide and tirzepatide, Papamargaritis says

Copper and zinc levels checked every 12 weeks can confirm that neither mineral is drifting outside healthy ranges

If dizziness occurs, sit or lie down until it passes

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