Enquanto o efeito do GIP quase completamente perdido na diabetes mellitus tipo 2, a GLP-1 mantm a sua actividade estimulante [1], razo pela qual o foco teraputico a GLP-1 (Fig
Studies in sebocytes show GHK suppresses IL-6 gene expression, contributing to reduced inflammatory signaling
The compound showed an in vitro NNMT IC 50 of approximately 1.2 M and did not inhibit related methyltransferases at concentrations tested
[1] Some patients have reported mood changes, anxiety, or depressive symptoms while taking medications in this class, but establishing causality is challenging
1, Table 2 and Supplementary Section 5) seems more likely, while any effect on psychotic, mood and anxiety disorders appears less consistent and in need of further investigation
Pradhan R, Montastruc F, Rousseau V, Patorno E, Azoulay L