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Redox-based regulation of signal transduction: principles, pitfalls, and promises

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The most crucial factor is size: conformational structure, targeted size (1 and 200 nm), high drug loading efficiency, a long half-life in circulation with minimal systemic toxicity, selective localization, and high adhesion in the tumour environment (97)

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It has been demonstrated that dendritic cells downregulate CD80 expression, preventing T cell activation via CD28, and exhibit high amounts of PD-L1

(2021) 13:e20483