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Some people say they experience abdominal cramps, bloating or allergic reactions such as rashes and itching
However, with few clinical trials, it requires consistent, long-term use to achieve and sustain results
Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety
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Additional preclinical themes include angiogenesis (through endothelial cell migration and tube formation), modulation of inflammatory signalling, and reported effects on cardiac, dermal and neural tissue in animal models
