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Ferroptosis is an innovative mechanism of cell death that is mostly caused by the deposition of lipid peroxides and unevenness in the regulation of iron levels due to disruption of intracellular metabolic pathways

Consistent with this, FGF21 is induced by lipid accumulation in cardiomyocytes ( Nervous System The cytoprotective effects of FGF21, whether direct or indirect, are also evident in the nervous system, where FGF21 treatment attenuates neuroinflammation, neuronal oxidative stress, and neurodegeneration and preserves cognitive function in diabetic mice and high fat fed rats (270, 271)

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