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Studies of endogenous GLP-1 release and administration of long acting GLP-1 agonists show two mechanisms of action (78)

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In specific cell lines expressing recombinant human GLP-1 receptors, the action of GLP-1 analogs can stimulate the expression of intracellular cAMP

Ten additional disulphide stabilised exendin-4 antibody fusions were produced (Supplementary Table 5) and, following protein A purification, four of these fusions presented a reduction in aggregate formation compared to Ab#2_DSB#1 (Fig