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Nat Med 25:403418
As seen in Supplemental Figure 4B, the sum of total intracellular hydroperoxy- and hydroxy-phospholipids following IL-13 stimulation was approximately 2 nmol/mg protein, that is, sufficient amounts to quantifiably impact the change in intracellular GSH (and the increases in GSSG) under these two conditions, as shown in Supplemental Figure 4C under similar conditions
By incorporating into the lipid membrane of local gastric cells, SNAC disturbs the fluidity of the membrane and increases intracellular accumulation of semaglutide via a transcellular process
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Elevated Bcl-2/Bax ratio and reduced cleaved caspase-3/PARP levels indicate anti-apoptotic mechanism