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4.5 Metabolic reprogramming and adipocyte crosstalk Metabolic reprogramming is one of the hallmarks of the breast cancer progression and is strongly influenced by the complex interactions among tumor cells and nearby adipocytes present within the TME (122, 123)

Cells were imaged in fresh FluoroBrite DMEM supplemented with 4 mM glutamine, 1 mM sodium pyruvate, 10% FBS and penicillin (100 U ml 1 )/streptomycin (100 g ml 1 )/fungizone (0.25 g ml 1 )

Cyanocobalamin, also known as Vitamin B12, is essential for energy production, nerve function, and red blood cell formation

Most studies indicate it may only work on sun-exposed areas and in specific age groups over 40 years old